blood Multiple Myeloma Articles

María-Victoria Mateos, Joaquín Martínez-López, Miguel-Teodoro Hernández, Enrique-M. Ocio, Laura Rosiñol, Rafael Martínez, Ana-Isabel Teruel, Norma C. Gutiérrez, María-Luisa Martín Ramos, Albert Oriol, Joan Bargay, Enrique Bengoechea, Yolanda González, Jaime Pérez de Oteyza, Mercedes Gironella, Cristina Encinas, Jesús Martín, Carmen Cabrera, Bruno Paiva, María-Teresa Cedena, Noemí Puig, Joan Bladé, Juan-José Lahuerta, Jesús San-Miguel
Jan 28, 2016
Rabya H. Sayed, Ashutosh D. Wechalekar, Janet A. Gilbertson, Paul Bass, Shameem Mahmood, Sajitha Sachchithanantham, Marianna Fontana, Ketna Patel, Carol J. Whelan, Helen J. Lachmann, Philip N. Hawkins, Julian D. Gillmore
Dec 24, 2015
Jatin J. Shah, Edward A. Stadtmauer, Rafat Abonour, Adam D. Cohen, William I. Bensinger, Cristina Gasparetto, Jonathan L. Kaufman, Suzanne Lentzsch, Dan T. Vogl, Christina L. Gomes, Natalia Pascucci, David D. Smith, Robert Z. Orlowski, Brian G. M. Durie
Nov 12, 2015
Rowan Kuiper, Mark van Duin, Martin H. van Vliet, Annemiek Broijl, Bronno van der Holt, Laila el Jarari, Erik H. van Beers, George Mulligan, Hervé Avet-Loiseau, Walter M. Gregory, Gareth Morgan, Hartmut Goldschmidt, Henk M. Lokhorst, Pieter Sonneveld
Oct 22, 2015
Jatin J. Shah, Edward A. Stadtmauer, Rafat Abonour, Adam D. Cohen, William I. Bensinger, Cristina Gasparetto, Jonathan L. Kaufman, Suzanne Lentzsch, Dan T. Vogl, Christina L. Gomes, Natalia Pascucci, David D. Smith, Robert Z. Orlowski, Brian G.M. Durie
Sep 24, 2015
Sagar Lonial, Lawrence H. Boise, Jonathan Kaufman
Sep 24, 2015

ASH ® Image Bank

 

Four-nucleate plasma cell in multiple myeloma (bone marrow smear; Pappenheim staining).

 

Flame cells are plasma cells with a distinctive reddish hue which accumulates around the peripheral areas of the cell. The color is due to accumulation of immunoglobulin.

 

Lung biopsy demonstrates an interalveolar infiltrate of plasma cells (arrows) in a patient with a previous diagnosis of multiple myeloma.

 

A 54-year-old male presented with right shoulder pain of several weeks duration. Skeletal survey did not reveal any lytic lesions. Bone marrow biopsy did not show a plasmacytosis.

 

Flame Cells: These are plasma cells with vermillion-staining glycogen-rich overstuffed fibrils. Although these cytoplasmic features are suggestive of neoplastic plasma cells, they can also be found in reactive cells as well. They are also thought to be heavily associated with IgA myelomas, however they can also be associated with IgG, and IgM myeloma.

 

Heavily granulated myeloma cells. Some cells contain Auer rod-like granules.

 

Arrows mark plasma cells with Dutcher bodies.

 

Snapper-Schneid granules are ovoid shaped basophilic inclusions which represent precipitated immunoglobulin. They can be seen in myeloma cells.

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blood How I Treat

Alessandra Larocca, Antonio Palumbo
Nov 05, 2015
Sagar Lonial, Lawrence H. Boise, Jonathan Kaufman
Sep 24, 2015

My Say

A reflection on Myeloma Treatment Advances

A. Keith Stewart, MBChB

Anna Maria and Vasek Polak Professor of Cancer Research
Dean for Research Division of Hematology-Oncology
Mayo Clinic
Scottsdale, Arizona

 

Featured Image

Consult a Colleague

Consult a Colleague is a service for ASH® members that helps facilitate the exchange of information between hematologists and their peers
 

 

Feature Editor: Dr. Keith Stewart