blood Multiple Myeloma Articles

Zheng Chen , Robert Z. Orlowski , Michael Wang , Larry Kwak , Nami McCarty
Apr 03, 2014
Paul G. Richardson , David S. Siegel , Ravi Vij , Craig C. Hofmeister , Rachid Baz , Sundar Jagannath , Christine Chen , Sagar Lonial , Andrzej Jakubowiak , Nizar Bahlis , Kevin Song , Andrew Belch , Noopur Raje , Chaim Shustik , Suzanne Lentzsch , Martha Lacy , Joseph Mikhael , Jeffrey Matous , David Vesole , Min Chen , Mohamed H. Zaki , Christian Jacques , Zhinuan Yu , Kenneth C. Anderson
Mar 20, 2014
Jeanette Ramos , Robert Lorsbach
Mar 13, 2014
Zachary R. Hunter , Lian Xu , Guang Yang , Yangsheng Zhou , Xia Liu , Yang Cao , Robert J. Manning , Christina Tripsas , Christopher J. Patterson , Patricia Sheehy , Steven P. Treon
Mar 13, 2014
Paul G. Richardson , Wanling Xie , Sundar Jagannath , Andrzej Jakubowiak , Sagar Lonial , Noopur S. Raje , Melissa Alsina , Irene M. Ghobrial , Robert L. Schlossman , Nikhil C. Munshi , Amitabha Mazumder , David H. Vesole , Jonathan L. Kaufman , Kathleen Colson , Mary McKenney , Laura E. Lunde , John Feather , Michelle E. Maglio , Diane Warren , Dixil Francis , Teru Hideshima , Robert Knight , Dixie-Lee Esseltine , Constantine S. Mitsiades , Edie Weller , Kenneth C. Anderson
Mar 06, 2014
Oana M. Mereuta , Jason D. Theis , Julie A. Vrana , Mark E. Law , Karen L. Grogg , Surendra Dasari , Vishal S. Chandan , Tsung-Teh Wu , Victor H. Jimenez-Zepeda , Rafael Fonseca , Angela Dispenzieri , Paul J. Kurtin , Ahmet Dogan
Mar 06, 2014

ASH ® Image Bank

Four-nucleate plasma cell in multiple myeloma (bone marrow smear; Pappenheim staining).

Flame cells are plasma cells with a distinctive reddish hue which accumulates around the peripheral areas of the cell. The color is due to accumulation of immunoglobulin.

Lung biopsy demonstrates an interalveolar infiltrate of plasma cells (arrows) in a patient with a previous diagnosis of multiple myeloma.

A 54-year-old male presented with right shoulder pain of several weeks duration. Skeletal survey did not reveal any lytic lesions. Bone marrow biopsy did not show a plasmacytosis.

Flame Cells: These are plasma cells with vermillion-staining glycogen-rich overstuffed fibrils. Although these cytoplasmic features are suggestive of neoplastic plasma cells, they can also be found in reactive cells as well. They are also thought to be heavily associated with IgA myelomas, however they can also be associated with IgG, and IgM myeloma.

Heavily granulated myeloma cells. Some cells contain Auer rod-like granules.

Arrows mark plasma cells with Dutcher bodies.

Snapper-Schneid granules are ovoid shaped basophilic inclusions which represent precipitated immunoglobulin. They can be seen in myeloma cells.


blood How I Treat

Jean-Paul Fermand , Frank Bridoux , Robert A. Kyle , Efstathios Kastritis , Brendan M. Weiss , Mark A. Cook , Mark T. Drayson , Angela Dispenzieri , Nelson Leung
Nov 21, 2013
Nelson Leung , Samih H. Nasr , Sanjeev Sethi
Oct 18, 2012

My Say

A reflection on Myeloma Treatment Advances

A. Keith Stewart, MBChB

Anna Maria and Vasek Polak Professor of Cancer Research
Dean for Research Division of Hematology-Oncology
Mayo Clinic
Scottsdale, Arizona


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Consult a Colleague

Consult a Colleague is a service for ASH® members that helps facilitate the exchange of information between hematologists and their peers


Feature Editor: Dr. Keith Stewart