blood Multiple Myeloma Articles

David Avigan, Jacalyn Rosenblatt
Jun 14, 2018
Bruce R. Blazar, Kelli P. A. MacDonald, Geoffrey R. Hill
Jun 14, 2018
Eytan M. Stein, Guillermo Garcia-Manero, David A. Rizzieri, Raoul Tibes, Jesus G. Berdeja, Michael R. Savona, Mojca Jongen-Lavrenic, Jessica K. Altman, Blythe Thomson, Stephen J. Blakemore, Scott R. Daigle, Nigel J. Waters, A. Benjamin Suttle, Alicia Clawson, Roy Pollock, Andrei Krivtsov, Scott A. Armstrong, Jorge DiMartino, Eric Hedrick, Bob Löwenberg, Martin S. Tallman
Jun 14, 2018
Lene Sofie Granfeldt Østgård, Mette Nørgaard, Bruno C. Medeiros, Marianne Tang Severinsen, Lone Smidstrup Friis, Claus Werenberg Marcher, Claudia Schoellkopf, Jan Maxwell Nørgaard
Jun 14, 2018
M. Laura Avila, Nour Amiri, Sanja Stanojevic, Trang T. Vu, Katherine Barron, Peter Krol, Natasha Yue, Suzan Williams, Leonardo R. Brandão
Jun 14, 2018

ASH ® Image Bank


Four-nucleate plasma cell in multiple myeloma (bone marrow smear; Pappenheim staining).


Flame cells are plasma cells with a distinctive reddish hue which accumulates around the peripheral areas of the cell. The color is due to accumulation of immunoglobulin.


Lung biopsy demonstrates an interalveolar infiltrate of plasma cells (arrows) in a patient with a previous diagnosis of multiple myeloma.


A 54-year-old male presented with right shoulder pain of several weeks duration. Skeletal survey did not reveal any lytic lesions. Bone marrow biopsy did not show a plasmacytosis.


Flame Cells: These are plasma cells with vermillion-staining glycogen-rich overstuffed fibrils. Although these cytoplasmic features are suggestive of neoplastic plasma cells, they can also be found in reactive cells as well. They are also thought to be heavily associated with IgA myelomas, however they can also be associated with IgG, and IgM myeloma.


Heavily granulated myeloma cells. Some cells contain Auer rod-like granules.


Arrows mark plasma cells with Dutcher bodies.


Snapper-Schneid granules are ovoid shaped basophilic inclusions which represent precipitated immunoglobulin. They can be seen in myeloma cells.


blood How I Treat

Franco Locatelli, Brigitte Strahm
Mar 29, 2018
Rebecca Kruse-Jarres, Jill M. Johnsen
Mar 22, 2018

My Say

A reflection on Myeloma Treatment Advances

A. Keith Stewart, MBChB

Anna Maria and Vasek Polak Professor of Cancer Research
Dean for Research Division of Hematology-Oncology
Mayo Clinic
Scottsdale, Arizona


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Consult a Colleague

Consult a Colleague is a service for ASH® members that helps facilitate the exchange of information between hematologists and their peers


Feature Editor: Dr. Keith Stewart