blood Multiple Myeloma Articles

Joaquín Martínez-López, Bruno Paiva, Lucía López-Anglada, María-Victoria Mateos, Teresa Cedena, María-Belén Vidríales, María Auxiliadora Sáez-Gómez, Teresa Contreras, Albert Oriol, Inmaculada Rapado, Ana-Isabel Teruel, Lourdes Cordón, María Jesús Blanchard, Enrique Bengoechea, Luis Palomera, Felipe de Arriba, Cecilia Cueto-Felgueroso, Alberto Orfao, Joan Bladé, Jesús F. San Miguel, Juan José Lahuerta, Carmen Menchaca, José María Guinea, María Blanca Villarubia, Abelardo Bárez, Jorge Groiss, Inmaculada Fuentes, Carlos López, Rafael Ramos, Joan Besalduch, Antonia Sampol, Joan Bargay, Eugenia Abella, Joan Bladé, Miguel Granell, Albert Oriol, Elena Cabezudo, Germán las Heras, Juan Alfonso Soler, Elena Rámila, Antonio Asensio, Mercedes Gironella, Dolors Badenes, Rosa María López, Juan Miguel Bergua, María Luisa Martín, María Mas, José Luis Bello, Yolanda González, Enrique Bengoechea, María Asunción Echeveste, Anastasia Aulés, Carmen Aguilera, Jesús Arias, Nicolás Díaz, Dolores Hernández, Raquel de Paz, María Jesús Blanchard, Juan José Lahuerta, Isabel Krsnik Castello, Joaquín Díaz-Mediavilla, Rafael Martínez, Adrián Alegre, Elena Prieto, Rafael Flores, Esther Jaro, Nieves Somolinos, Francisco Javier Peñalver, José Francisco Tomás, Felipe de Arriba, Jerónima Ibáñez, Julio Esteban, María Ángeles Goñi, José María Arguiñano, Jesús F. San Miguel, Felipe Prósper, Fernando Ortega, Alexia Suárez, Santiago Jiménez, José Manuel Calvo, María José Allegue, Carmen Albó, Concha Poderós, Manuel Constenla, Marivi Mateos, Miguel Teodoro Hernández, Bernardo J. González, Eulogio Conde, José Mariano Hernández, Lourdes Escoda, Marta Cervera, Javier de la Rubia, Paz Ribas, Aurelio López, Ana Isabel Teruel, Amparo Avaria, María Ángeles Ruíz, María José Fernández, Isabel Navarro Gonzalo, Javier García-Frade, Elena Fernández, Alfonso García de Coca, Rebeca Cuello, Fernando Marco, José María Beltrán de Heredia, Juan Carlos García-Ruíz, Jesús María Ojanguren, Monserrat Pérez, Luis Palomera, Araceli Rubio, Luis López, Vicente Carrasco
Aug 13, 2015
Giovanni Palladini, Sajitha Sachchithanantham, Paolo Milani, Julian Gillmore, Andrea Foli, Helen Lachmann, Marco Basset, Philip Hawkins, Giampaolo Merlini, Ashutosh D. Wechalekar
Jul 30, 2015
Giada Bianchi, Paul G. Richardson, Kenneth C. Anderson
Jul 16, 2015
Kartik Sehgal, Rituparna Das, Lin Zhang, Rakesh Verma, Yanhong Deng, Mehmet Kocoglu, Juan Vasquez, Srinivas Koduru, Yan Ren, Maria Wang, Suzana Couto, Mike Breider, Donna Hansel, Stuart Seropian, Dennis Cooper, Anjan Thakurta, Xiaopan Yao, Kavita M. Dhodapkar, Madhav V. Dhodapkar
Jun 25, 2015
Jeffrey R. Sawyer, Erming Tian, Christoph J. Heuck, Donald J. Johann, Joshua Epstein, Charles M. Swanson, Janet L. Lukacs, Regina Lichti Binz, Marian Johnson, Gael Sammartino, Maurizio Zangari, Faith E. Davies, Frits van Rhee, Gareth J. Morgan, Bart Barlogie
Jun 11, 2015
Timothy N. Trotter, Mei Li, Qianying Pan, Deniz Peker, Patrick D. Rowan, Juan Li, Fenghuang Zhan, Larry J. Suva, Amjad Javed, Yang Yang
Jun 04, 2015

ASH ® Image Bank

Four-nucleate plasma cell in multiple myeloma (bone marrow smear; Pappenheim staining).

Flame cells are plasma cells with a distinctive reddish hue which accumulates around the peripheral areas of the cell. The color is due to accumulation of immunoglobulin.

Lung biopsy demonstrates an interalveolar infiltrate of plasma cells (arrows) in a patient with a previous diagnosis of multiple myeloma.

A 54-year-old male presented with right shoulder pain of several weeks duration. Skeletal survey did not reveal any lytic lesions. Bone marrow biopsy did not show a plasmacytosis.

Flame Cells: These are plasma cells with vermillion-staining glycogen-rich overstuffed fibrils. Although these cytoplasmic features are suggestive of neoplastic plasma cells, they can also be found in reactive cells as well. They are also thought to be heavily associated with IgA myelomas, however they can also be associated with IgG, and IgM myeloma.

Heavily granulated myeloma cells. Some cells contain Auer rod-like granules.

Arrows mark plasma cells with Dutcher bodies.

Snapper-Schneid granules are ovoid shaped basophilic inclusions which represent precipitated immunoglobulin. They can be seen in myeloma cells.

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blood How I Treat

Joan Bladé, Laura Rosiñol, Carlos Fernández de Larrea
Mar 05, 2015
Irene M. Ghobrial, Ola Landgren
Nov 27, 2014

My Say

A reflection on Myeloma Treatment Advances

A. Keith Stewart, MBChB

Anna Maria and Vasek Polak Professor of Cancer Research
Dean for Research Division of Hematology-Oncology
Mayo Clinic
Scottsdale, Arizona

 

Featured Image

Consult a Colleague

Consult a Colleague is a service for ASH® members that helps facilitate the exchange of information between hematologists and their peers
 

 

Feature Editor: Dr. Keith Stewart