blood Multiple Myeloma Articles

Eugenio Morelli, Lavinia Biamonte, Cinzia Federico, Nicola Amodio, Maria Teresa Di Martino, Maria Eugenia Gallo Cantafio, Martina Manzoni, Francesca Scionti, Mehmet Kemal Samur, Annamaria Gullà, Maria Angelica Stamato, Maria Rita Pitari, Daniele Caracciolo, Settimio Sesti, Niels M. Frandsen, Marco Rossi, Antonino Neri, Mariateresa Fulciniti, Nikhil C. Munshi, Pierosandro Tagliaferri, Pierfrancesco Tassone
Jul 16, 2018
Pieter F. van der Meer, Paula F. Ypma, Nan van Geloven, Joost A. van Hilten, Rinie J. van Wordragen-Vlaswinkel, Okke Eissen, Jaap J. Zwaginga, Michael Trus, Erik A. M. Beckers, Peter te Boekhorst, Alan Tinmouth, Yulia Lin, Cyrus Hsia, David Lee, Philip J. Norris, Raymond P. Goodrich, Anneke Brand, Tor Hervig, Nancy M. Heddle, Johanna G. van der Bom, Jean-Louis H. Kerkhoffs
Jul 12, 2018
Luca Ceriani, Lisa Milan, Maurizio Martelli, Andrés J. M. Ferreri, Luciano Cascione, Pier Luigi Zinzani, Alice Di Rocco, Annarita Conconi, Anastasios Stathis, Franco Cavalli, Monica Bellei, Kelly Cozens, Elena Porro, Luca Giovanella, Peter W. Johnson, Emanuele Zucca
Jul 12, 2018
Dean Bryant, Will Tapper, Nicola J. Weston-Bell, Arnold Bolomsky, Li Song, Shengtao Xu, Andrew R. Collins, Niklas Zojer, Surinder Singh Sahota
Jul 12, 2018
Ann S. LaCasce, R. Gregory Bociek, Ahmed Sawas, Paolo Caimi, Edward Agura, Jeffrey Matous, Stephen M. Ansell, Howland E. Crosswell, Miguel Islas-Ohlmayer, Caroline Behler, Eric Cheung, Andres Forero-Torres, Julie Vose, Owen A. O’Connor, Neil Josephson, Yinghui Wang, Ranjana Advani
Jul 05, 2018

ASH ® Image Bank

 

Four-nucleate plasma cell in multiple myeloma (bone marrow smear; Pappenheim staining).

 

Flame cells are plasma cells with a distinctive reddish hue which accumulates around the peripheral areas of the cell. The color is due to accumulation of immunoglobulin.

 

Lung biopsy demonstrates an interalveolar infiltrate of plasma cells (arrows) in a patient with a previous diagnosis of multiple myeloma.

 

A 54-year-old male presented with right shoulder pain of several weeks duration. Skeletal survey did not reveal any lytic lesions. Bone marrow biopsy did not show a plasmacytosis.

 

Flame Cells: These are plasma cells with vermillion-staining glycogen-rich overstuffed fibrils. Although these cytoplasmic features are suggestive of neoplastic plasma cells, they can also be found in reactive cells as well. They are also thought to be heavily associated with IgA myelomas, however they can also be associated with IgG, and IgM myeloma.

 

Heavily granulated myeloma cells. Some cells contain Auer rod-like granules.

 

Arrows mark plasma cells with Dutcher bodies.

 

Snapper-Schneid granules are ovoid shaped basophilic inclusions which represent precipitated immunoglobulin. They can be seen in myeloma cells.

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blood How I Treat

Eugenio Morelli, Lavinia Biamonte, Cinzia Federico, Nicola Amodio, Maria Teresa Di Martino, Maria Eugenia Gallo Cantafio, Martina Manzoni, Francesca Scionti, Mehmet Kemal Samur, Annamaria Gullà, Maria Angelica Stamato, Maria Rita Pitari, Daniele Caracciolo, Settimio Sesti, Niels M. Frandsen, Marco Rossi, Antonino Neri, Mariateresa Fulciniti, Nikhil C. Munshi, Pierosandro Tagliaferri, Pierfrancesco Tassone
Jul 16, 2018
Dean Bryant, Will Tapper, Nicola J. Weston-Bell, Arnold Bolomsky, Li Song, Shengtao Xu, Andrew R. Collins, Niklas Zojer, Surinder Singh Sahota
Jul 12, 2018

My Say

A reflection on Myeloma Treatment Advances

A. Keith Stewart, MBChB

Anna Maria and Vasek Polak Professor of Cancer Research
Dean for Research Division of Hematology-Oncology
Mayo Clinic
Scottsdale, Arizona

 

Featured Image

Consult a Colleague

Consult a Colleague is a service for ASH® members that helps facilitate the exchange of information between hematologists and their peers
 

 

Feature Editor: Dr. Keith Stewart