blood Multiple Myeloma Articles

Alexandre V. Hirayama, Jordan Gauthier, Kevin A. Hay, Jenna M. Voutsinas, Qian Wu, Barbara S. Pender, Reed M. Hawkins, Aesha Vakil, Rachel N. Steinmetz, Stanley R. Riddell, David G. Maloney, Cameron J. Turtle
Aug 15, 2019
Jeremy S. Abramson, Jon E. Arnason, Ann S. LaCasce, Robert Redd, Jeffrey A. Barnes, Lubomir Sokol, Robin Joyce, David Avigan, Donna Neuberg, Ronald W. Takvorian, Ephraim P. Hochberg, Celeste M. Bello
Aug 15, 2019
Hong-Hu Zhu, Jiong Hu, Francesco Lo-Coco, Jie Jin
Aug 15, 2019
Craig S. Sauter, Brigitte Senechal, Isabelle Rivière, Ai Ni, Yvette Bernal, Xiuyan Wang, Terence Purdon, Malloury Hall, Ashvin N. Singh, Victoria Z. Szenes, Sarah Yoo, Ahmet Dogan, Yongzeng Wang, Craig H. Moskowitz, Sergio Giralt, Matthew J. Matasar, Miguel-Angel Perales, Kevin J. Curran, Jae Park, Michel Sadelain, Renier J. Brentjens
Aug 15, 2019
Laura J. Janke, Sara L. Van Driest, Mary V. Portera, Ravi V. Atreya, Joshua C. Denny, Deqing Pei, Cheng Cheng, Sue C. Kaste, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Mary V. Relling, Seth E. Karol
Aug 13, 2019
Robert Chen, Pier Luigi Zinzani, Hun Ju Lee, Philippe Armand, Nathalie A. Johnson, Pauline Brice, John Radford, Vincent Ribrag, Daniel Molin, Theodoros P. Vassilakopoulos, Akihiro Tomita, Bastian von Tresckow, Margaret A. Shipp, Jianxin Lin, Eunhee Kim, Akash Nahar, Arun Balakumaran, Craig H. Moskowitz
Aug 13, 2019

ASH ® Image Bank

 

Four-nucleate plasma cell in multiple myeloma (bone marrow smear; Pappenheim staining).

 

Flame cells are plasma cells with a distinctive reddish hue which accumulates around the peripheral areas of the cell. The color is due to accumulation of immunoglobulin.

 

Lung biopsy demonstrates an interalveolar infiltrate of plasma cells (arrows) in a patient with a previous diagnosis of multiple myeloma.

 

A 54-year-old male presented with right shoulder pain of several weeks duration. Skeletal survey did not reveal any lytic lesions. Bone marrow biopsy did not show a plasmacytosis.

 

Flame Cells: These are plasma cells with vermillion-staining glycogen-rich overstuffed fibrils. Although these cytoplasmic features are suggestive of neoplastic plasma cells, they can also be found in reactive cells as well. They are also thought to be heavily associated with IgA myelomas, however they can also be associated with IgG, and IgM myeloma.

 

Heavily granulated myeloma cells. Some cells contain Auer rod-like granules.

 

Arrows mark plasma cells with Dutcher bodies.

 

Snapper-Schneid granules are ovoid shaped basophilic inclusions which represent precipitated immunoglobulin. They can be seen in myeloma cells.

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blood How I Treat

Shyril O'Steen, Melissa L. Comstock, Johnnie J. Orozco, Donald K. Hamlin, D. Scott Scott Wilbur, Jon C. Jones, Aimee Kenoyer, Margaret E. Nartea, Yukang Lin, Brian W. Miller, Theodore A. Gooley, Sherilyn A Tuazon, Brian G. Till, Ajay K. Gopal, Brenda M. Sandmaier, Oliver W. Press, Damian J. Green
Aug 08, 2019
Michi M. Shinohara, Andrei Shustov
Aug 08, 2019

My Say

A reflection on Myeloma Treatment Advances

A. Keith Stewart, MBChB

Anna Maria and Vasek Polak Professor of Cancer Research
Dean for Research Division of Hematology-Oncology
Mayo Clinic
Scottsdale, Arizona

 

Featured Image

Consult a Colleague

Consult a Colleague is a service for ASH® members that helps facilitate the exchange of information between hematologists and their peers
 

 

Feature Editor: Dr. Keith Stewart