blood Multiple Myeloma Articles

Donna E. Reece, Ute Hegenbart, Vaishali Sanchorawala, Giampaolo Merlini, Giovanni Palladini, Joan Bladé, Jean-Paul Fermand, Hani Hassoun, Leonard Heffner, Vishal Kukreti, Robert A. Vescio, Lixia Pei, Christopher Enny, Dixie-Lee Esseltine, Helgi van de Velde, Andrew Cakana, Raymond L. Comenzo
Oct 16, 2014
Giovanni Palladini, Ute Hegenbart, Paolo Milani, Christoph Kimmich, Andrea Foli, Anthony D. Ho, Marta Vidus Rosin, Riccardo Albertini, Remigio Moratti, Giampaolo Merlini, Stefan Schönland
Oct 09, 2014
Andrew Spencer, Sung-Soo Yoon, Simon J. Harrison, Shannon R. Morris, Deborah A. Smith, Richard A. Brigandi, Jennifer Gauvin, Rakesh Kumar, Joanna B. Opalinska, Christine Chen
Oct 02, 2014
Sarah K. Johnson, James P. Stewart, Rakesh Bam, Pingping Qu, Bart Barlogie, Frits van Rhee, John D. Shaughnessy Jr, Joshua Epstein, Shmuel Yaccoby
Sep 25, 2014
Zhiqiang Liu, Jingda Xu, Jin He, Yuhuan Zheng, Haiyan Li, Yong Lu, Jianfei Qian, Pei Lin, Donna M. Weber, Jing Yang, Qing Yi
Sep 25, 2014
Lawrence H. Boise, Jonathan L. Kaufman, Nizar J. Bahlis, Sagar Lonial, Kelvin P. Lee
Sep 18, 2014

ASH ® Image Bank

Four-nucleate plasma cell in multiple myeloma (bone marrow smear; Pappenheim staining).

Flame cells are plasma cells with a distinctive reddish hue which accumulates around the peripheral areas of the cell. The color is due to accumulation of immunoglobulin.

Lung biopsy demonstrates an interalveolar infiltrate of plasma cells (arrows) in a patient with a previous diagnosis of multiple myeloma.

A 54-year-old male presented with right shoulder pain of several weeks duration. Skeletal survey did not reveal any lytic lesions. Bone marrow biopsy did not show a plasmacytosis.

Flame Cells: These are plasma cells with vermillion-staining glycogen-rich overstuffed fibrils. Although these cytoplasmic features are suggestive of neoplastic plasma cells, they can also be found in reactive cells as well. They are also thought to be heavily associated with IgA myelomas, however they can also be associated with IgG, and IgM myeloma.

Heavily granulated myeloma cells. Some cells contain Auer rod-like granules.

Arrows mark plasma cells with Dutcher bodies.

Snapper-Schneid granules are ovoid shaped basophilic inclusions which represent precipitated immunoglobulin. They can be seen in myeloma cells.


blood How I Treat

Jean-Paul Fermand, Frank Bridoux, Robert A. Kyle, Efstathios Kastritis, Brendan M. Weiss, Mark A. Cook, Mark T. Drayson, Angela Dispenzieri, Nelson Leung
Nov 21, 2013

My Say

A reflection on Myeloma Treatment Advances

A. Keith Stewart, MBChB

Anna Maria and Vasek Polak Professor of Cancer Research
Dean for Research Division of Hematology-Oncology
Mayo Clinic
Scottsdale, Arizona


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Feature Editor: Dr. Keith Stewart