blood Multiple Myeloma Articles

Sarah K. Johnson , James P. Stewart , Rakesh Bam , Pingping Qu , Bart Barlogie , Frits van Rhee , John D. Shaughnessy Jr , Joshua Epstein , Shmuel Yaccoby
Sep 25, 2014
Zhiqiang Liu , Jingda Xu , Jin He , Yuhuan Zheng , Haiyan Li , Yong Lu , Jianfei Qian , Pei Lin , Donna M. Weber , Jing Yang , Qing Yi
Sep 25, 2014
Lawrence H. Boise , Jonathan L. Kaufman , Nizar J. Bahlis , Sagar Lonial , Kelvin P. Lee
Sep 18, 2014
María-Victoria Mateos , Albert Oriol , Joaquín Martínez-López , Ana-Isabel Teruel , Ana López de la Guía , Javier López , Enrique Bengoechea , Montserrat Pérez , Rafael Martínez , Luis Palomera , Felipe de Arriba , Yolanda González , José Mariano Hernández , Miquel Granell , José-Luis Bello , Joan Bargay , Francisco-Javier Peñalver , María-Luisa Martín-Mateos , Bruno Paiva , María-Angeles Montalbán , Joan Bladé , Juan-Jose Lahuerta , Jesús F. San-Miguel
Sep 18, 2014
Abdel Kareem Azab , Ilyas Sahin , Feda Azab , Michele Moschetta , Yuji Mishima , Nicholas Burwick , Johann Zimmermann , Barbara Romagnoli , Kalpana Patel , Eric Chevalier , Aldo M. Roccaro , Irene M. Ghobrial
Sep 18, 2014
Jagadish Kummetha Venkata , Ningfei An , Robert Stuart , Luciano J. Costa , Houjian Cai , Woodrow Coker , Jin H. Song , Kiwana Gibbs , Terri Matson , Elizabeth Garrett-Mayer , Zhuang Wan , Besim Ogretmen , Charles Smith , Yubin Kang
Sep 18, 2014

ASH ® Image Bank

Four-nucleate plasma cell in multiple myeloma (bone marrow smear; Pappenheim staining).

Flame cells are plasma cells with a distinctive reddish hue which accumulates around the peripheral areas of the cell. The color is due to accumulation of immunoglobulin.

Lung biopsy demonstrates an interalveolar infiltrate of plasma cells (arrows) in a patient with a previous diagnosis of multiple myeloma.

A 54-year-old male presented with right shoulder pain of several weeks duration. Skeletal survey did not reveal any lytic lesions. Bone marrow biopsy did not show a plasmacytosis.

Flame Cells: These are plasma cells with vermillion-staining glycogen-rich overstuffed fibrils. Although these cytoplasmic features are suggestive of neoplastic plasma cells, they can also be found in reactive cells as well. They are also thought to be heavily associated with IgA myelomas, however they can also be associated with IgG, and IgM myeloma.

Heavily granulated myeloma cells. Some cells contain Auer rod-like granules.

Arrows mark plasma cells with Dutcher bodies.

Snapper-Schneid granules are ovoid shaped basophilic inclusions which represent precipitated immunoglobulin. They can be seen in myeloma cells.


blood How I Treat

Jean-Paul Fermand , Frank Bridoux , Robert A. Kyle , Efstathios Kastritis , Brendan M. Weiss , Mark A. Cook , Mark T. Drayson , Angela Dispenzieri , Nelson Leung
Nov 21, 2013

My Say

A reflection on Myeloma Treatment Advances

A. Keith Stewart, MBChB

Anna Maria and Vasek Polak Professor of Cancer Research
Dean for Research Division of Hematology-Oncology
Mayo Clinic
Scottsdale, Arizona


Featured Image

Consult a Colleague

Consult a Colleague is a service for ASH® members that helps facilitate the exchange of information between hematologists and their peers


Feature Editor: Dr. Keith Stewart