blood Multiple Myeloma Articles

Giada Bianchi, Nikhil C. Munshi
May 14, 2015
Bruno Paiva, Jacques J. M. van Dongen, Alberto Orfao
May 14, 2015
S. Vincent Rajkumar, Ola Landgren, María-Victoria Mateos
May 14, 2015
Philippe Moreau, Michel Attal, Thierry Facon
May 14, 2015
Ajay K. Nooka, Efstathios Kastritis, Meletios A. Dimopoulos, Sagar Lonial
May 14, 2015

ASH ® Image Bank

Four-nucleate plasma cell in multiple myeloma (bone marrow smear; Pappenheim staining).

Flame cells are plasma cells with a distinctive reddish hue which accumulates around the peripheral areas of the cell. The color is due to accumulation of immunoglobulin.

Lung biopsy demonstrates an interalveolar infiltrate of plasma cells (arrows) in a patient with a previous diagnosis of multiple myeloma.

A 54-year-old male presented with right shoulder pain of several weeks duration. Skeletal survey did not reveal any lytic lesions. Bone marrow biopsy did not show a plasmacytosis.

Flame Cells: These are plasma cells with vermillion-staining glycogen-rich overstuffed fibrils. Although these cytoplasmic features are suggestive of neoplastic plasma cells, they can also be found in reactive cells as well. They are also thought to be heavily associated with IgA myelomas, however they can also be associated with IgG, and IgM myeloma.

Heavily granulated myeloma cells. Some cells contain Auer rod-like granules.

Arrows mark plasma cells with Dutcher bodies.

Snapper-Schneid granules are ovoid shaped basophilic inclusions which represent precipitated immunoglobulin. They can be seen in myeloma cells.


blood How I Treat

Joan Bladé, Laura Rosiñol, Carlos Fernández de Larrea
Mar 05, 2015
Irene M. Ghobrial, Ola Landgren
Nov 27, 2014

My Say

A reflection on Myeloma Treatment Advances

A. Keith Stewart, MBChB

Anna Maria and Vasek Polak Professor of Cancer Research
Dean for Research Division of Hematology-Oncology
Mayo Clinic
Scottsdale, Arizona


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Feature Editor: Dr. Keith Stewart